Pathways for interleukin-1-driven arthritis
نویسندگان
چکیده
منابع مشابه
Interleukin-1, immune activation pathways, and different mechanisms in osteoarthritis and rheumatoid arthritis.
The properties of interleukin-l suggest that it has a central role in the immunopathology of many arthritides (figure). It is now more than 10 years since it was realised that numerous biological activities were due to a single agent called interleukin-I (IL-I)' (now known to be two related proteins, IL-la and IL-l132). The functions of IL-1, such as T cell activation,3 stimulation of cellular ...
متن کاملArguments for interleukin 1 as a target in chronic arthritis.
Tumour necrosis factor (TNF) and interleukin 1 (IL1) are considered as master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatic arthritis (RA) patients so far mainly focused on TNF. Although TNF is a major inflammatory mediator in RA and a potent inducer of IL1, anti-TNF treatment is not effective in all patients, nor does it fully control the arthritic process in...
متن کاملRole of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis.
Chronic arthritis is characterised by chronic joint inflammation and concurrent joint erosion and destruction. The inflammatory cytokine interleukin 1 (IL1) has been shown to be a key mediator in the autoimmune disease rheumatoid arthritis (RA). Interleukin 1 mediates bone resorption and cartilage destruction, but may not play as dominant a part in joint swelling and inflammation. Interleukin 1...
متن کاملTreatment of rheumatoid arthritis with interleukin 1 receptor antagonist.
PURPOSE Interleukin -1 receptor antagonist ( IL-1Ra ) is a new option among biotherapies against rheumatoid arthritis ( RA ). THE AIM of this review is to recall the rationale of use of IL-1Ra and to analyse the results available in the current literature. CURRENT KNOWLEDGE AND KEY POINTS Pathophysiological data of RA give a specific position for IL-1 as a potential target for immunotherapy...
متن کاملInterleukin-1 expression by neutrophils in rheumatoid arthritis.
OBJECTIVE To determine if neutrophils from blood and synovial fluid of patients with rheumatoid arthritis and other joint arthropathies express interleukin-1 beta mRNA. METHODS RNA was isolated from neutrophils from patient and control blood, and synovial fluid of patients, probed in northern blots, and quantified by densitometry. It was also isolated and analysed from control blood neutrophi...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2008
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.23952